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Diiodotyrosine

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Not to be confused with diiodothyronine.

Diiodotyrosine (DIT) is a precursor in the production of thyroid hormone, and results from iodization of monoiodotyrosine at the other meta- position on the phenol ring.


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Function

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DIT is a modulator of the enzyme thyroid peroxidase (which is involved in the production of thyroid hormones).

Triiodothyronine is formed, when diiodotyrosine is combined with monoiodotyrosine (in the colloid of the thyroid follicle).

Two molecules of DIT combine to make the thyroid hormone thyroxine ('T4' and 'T3').


See also

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• Diiodotyrosine transaminase

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